Tributylamine diphosphate

Base Information

• Chemical Name: Tributylamine diphosphate
• CAS No.: 5975-18-8
• Molecular Formula: 2C₁₂H₂₇N*H₄O₇P₂
• Molecular Weight: 548.681
• Mol file: 5975-18-8.mol

Synonyms:55612-36-7;Tributylamine diphosphate;Tributylamine xdiphosphate;SCHEMBL73402;AKOS015913197;CID 13915987;50859-18-2

Chemical Property of Tributylamine diphosphate

Chemical Property:

• PSA: 150.39000
• LogP: 6.56580
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 363.15757632
• Heavy Atom Count: 22
• Complexity: 220

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tributylammonium pyrophosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN(CCCC)CCCC.OP(=O)(O)OP(=O)(O)O
• Description: Tributylammonium pyrophosphate is a phosphorylating reagent used in the synthesis of phosphorylated nucleosides, particularly nucleoside triphosphates used as building blocks for the synthesis of DNA, RNA and sugar nucleotides; as well as a source of cellular energy. Nucleoside triphosphates are typically synthesised by treating free nucleosides with phosphorus oxychloride, then adding tributylammonium pyrophosphate to the reaction intermediate, where the lipophilic tributylammonium salt enhances solubility in organic solvents. Additionally, tributylammonium pyrophosphate was used in the preparation of structurally complex dinucleotide-5’-triphosphates.
• Uses: Bis(tributylammonium) Pyrophosphate is an phosphorylating reagent used in the synthesis of phosphorylated deoxynucleosides.Reactant for:Enzymic synthesis of 3′-deoxy-apio-nucleic acid duplexesSynthesis of deoxynucleoside S-methylphosphonic acidsPreparation of fluorescent non-nucleotide ATP analog N-methylanthraniloylamideethyl triphosphateUseful in triphosphate synthesis because of its low water content and high solubility in organic solvents. Reactant for:Enzymic synthesis of 3′-deoxy-apio-nucleic acid duplexesSynthesis of deoxynucleoside S-methylphosphonic acidsPreparation of fluorescent non-nucleotide ATP analog N-methylanthraniloylamideethyl triphosphate

Technology Process of Tributylamine diphosphate

There total 5 articles about Tributylamine diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tributyl-amine (102-82-9) → bis(tri-n-butylammonium) pyrophosphate (5975-18-8,50859-18-2,55612-36-7,88499-44-9,103659-66-1)

Guidance literature:

With tetrasodium pyrophosphate decahydrate; In water; Cooling with ice;

DOI:10.1039/c7cc06703h

Reference yield: 76.0%

tributyl-amine (102-82-9) → tri(n-butyl)ammonium pyrophosphate (5975-18-8,50859-18-2,55612-36-7,88499-44-9,103659-66-1)

Guidance literature:

With pyrophosphoric acid; In ethanol; water; at 0 ℃;

DOI:10.1021/ol1004214

Reference yield:

tributyl-amine (102-82-9) + tetrasodium diphosphate decahydrate → bis(tri-n-butylammonium) pyrophosphate (5975-18-8,50859-18-2,55612-36-7,88499-44-9,103659-66-1)

Guidance literature:

In ethanol; water;

DOI:10.1002/cjoc.201300440

upstream raw materials:

tributyl-amine

phosphoric acid

Downstream raw materials:

L(-)FMAUTP

5-methoxycarbonylmethyl-2'-O-methyl-uridine