Chemical Property of Tributylamine diphosphate
Chemical Property:
- PSA：150.39000
- LogP:6.56580
- Storage Temp.:−20°C
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:11
- Exact Mass:363.15757632
- Heavy Atom Count:22
- Complexity:220
- Purity/Quality:
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99%, *data from raw suppliers
Tributylammonium pyrophosphate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCN(CCCC)CCCC.OP(=O)(O)OP(=O)(O)O
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Description
Tributylammonium pyrophosphate is a phosphorylating reagent used in the synthesis of phosphorylated nucleosides, particularly nucleoside triphosphates used as building blocks for the synthesis of DNA, RNA and sugar nucleotides; as well as a source of cellular energy. Nucleoside triphosphates are typically synthesised by treating free nucleosides with phosphorus oxychloride, then adding tributylammonium pyrophosphate to the reaction intermediate, where the lipophilic tributylammonium salt enhances solubility in organic solvents. Additionally, tributylammonium pyrophosphate was used in the preparation of structurally complex dinucleotide-5’-triphosphates.
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Uses
Bis(tributylammonium) Pyrophosphate is an phosphorylating reagent used in the synthesis of phosphorylated deoxynucleosides.Reactant for:Enzymic synthesis of 3′-deoxy-apio-nucleic acid duplexesSynthesis of deoxynucleoside S-methylphosphonic acidsPreparation of fluorescent non-nucleotide ATP analog N-methylanthraniloylamideethyl triphosphateUseful in triphosphate synthesis because of its low water content and high solubility in organic solvents. Reactant for:Enzymic synthesis of 3′-deoxy-apio-nucleic acid duplexesSynthesis of deoxynucleoside S-methylphosphonic acidsPreparation of fluorescent non-nucleotide ATP analog N-methylanthraniloylamideethyl triphosphate
