((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Base Information

• Chemical Name: ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
• CAS No.: 90015-82-0
• Molecular Formula: C12H22N3O14P3
• Molecular Weight: 523.224
• Mol file: 90015-82-0.mol

Synonyms:[(2R,3R,5R)-5-[5-(3-aminopropyl)-2,4-dioxo-pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate

Chemical Property of ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Chemical Property:

• Refractive Index: 1.602
• PSA: 299.59000
• Density: 1.819 g/cm³
• LogP: -0.88010

Purity/Quality:

97% ^*data from raw suppliers

((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

There total 2 articles about ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allylamine acetate + C9H14ClHgN2O14P3 → 5-[3-aminoallyl]-2'-deoxy-uridine 5'-triphosphate (90015-82-0)

Guidance literature:

With sodium acetate; lithium tetrachloropalladate; In water; at 20 ℃; for 24h; pH=5.0;

Reference yield:

Allylamine-deoxyuridine + 5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine (96102-22-6) + tributyl-amine (102-82-9) + triethylamine carbonate (15715-58-9) + tri(n-butyl)ammonium pyrophosphate (5975-18-8,50859-18-2,55612-36-7,88499-44-9,103659-66-1) → 5-[3-aminoallyl]-2'-deoxy-uridine 5'-triphosphate (90015-82-0)

Guidance literature:

With ammonium hydroxide; trichlorophosphate; In trimethyl phosphite; N,N-dimethyl-formamide; acetonitrile;

Reference yield: 48.9%

5-[3-aminoallyl]-2'-deoxy-uridine 5'-triphosphate (90015-82-0) + C27H15NO8S → C39H35N4O22P3S

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 20h;

upstream raw materials:

5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine

tributyl-amine

triethylamine carbonate

tri(n-butyl)ammonium pyrophosphate

Downstream raw materials:

SITC-dUTP