(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

Base Information

Chemical Name:(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole
CAS No.:128592-35-8
Molecular Formula:C₂₃H₂₄N₂O₃S
Molecular Weight:408.521
Hs Code.:

Synonyms:(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

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Chemical Property of (S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

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Technology Process of (S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

There total 5 articles about (S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 128592-31-4
(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 128592-35-8
(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-33-6
(R)-3-(3-Hydroxy-propyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 128592-35-8
(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

4: 88 percent / Ph₃P / tetrahydrofuran / 24 h / 20 °C

With sodium hydroxide; sodium azide; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-32-5
3-((R)-3-Methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-propionic acid methyl ester

: 128592-35-8
(S)-7-(4-Methoxy-benzenesulfonyl)-4a-methyl-2,4,4a,5,6,7-hexahydro-3H-pyrido[3,2-c]carbazole

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / LiEt₃BH / tetrahydrofuran / 1 h / -10 °C

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaN₃ / dimethylformamide / 3 h / 80 °C

4: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

5: 88 percent / Ph₃P / tetrahydrofuran / 24 h / 20 °C

With sodium hydroxide; sodium azide; tetra(n-butyl)ammonium hydrogensulfate; lithium triethylborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9