(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

Base Information

Chemical Name:(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one
CAS No.:128592-31-4
Molecular Formula:C₂₃H₂₄N₄O₄S
Molecular Weight:452.534
Hs Code.:

Synonyms:(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

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Chemical Property of (S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

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Technology Process of (S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

There total 4 articles about (S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 128592-34-7
(S)-3-(3-Azido-propyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 128592-31-4
(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-33-6
(R)-3-(3-Hydroxy-propyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

: 128592-31-4
(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: NaN₃ / dimethylformamide / 3 h / 80 °C

3: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; sodium azide; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9

Reference yield:

: 128592-32-5
3-((R)-3-Methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-propionic acid methyl ester

: 128592-31-4
(S)-3-(3-Azido-propyl)-9-(4-methoxy-benzenesulfonyl)-3-methyl-1,2,3,9-tetrahydro-carbazol-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / LiEt₃BH / tetrahydrofuran / 1 h / -10 °C

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: NaN₃ / dimethylformamide / 3 h / 80 °C

4: 93 percent / 50percent NaOH, n-Bu₄N*HSO₄ / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; sodium azide; tetra(n-butyl)ammonium hydrogensulfate; lithium triethylborohydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94654-9