N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

Base Information

Chemical Name:N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide
CAS No.:1403473-75-5
Molecular Formula:C₂₆H₂₅ClN₄O₆
Molecular Weight:524.961
Hs Code.:

Synonyms:N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

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Chemical Property of N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

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Technology Process of N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

There total 5 articles about N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1030152-66-9
5-(4-chlorophenyl)-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide

: 118684-32-5
[3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide

: 1403473-75-5
N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

Guidance literature:: 5-(4-chlorophenyl)-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide; With sodium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;

[3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 34035-03-5
5-(4-chlorophenyl)-2-furaldehyde

: 1403473-75-5
N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

3.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere

3.2: 4 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 106-39-8
bromochlorobenzene

: 1403473-75-5
N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(4-chlorophenyl)-2-furamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; 1,2-dimethoxyethane / 2 h / 60 °C

2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.08.062