6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

Base Information

Chemical Name:6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol
CAS No.:1346816-86-1
Molecular Formula:C₂₀H₁₇FN₆O₂
Molecular Weight:392.392
Hs Code.:

Synonyms:6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

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Chemical Property of 6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

Chemical Property:

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Technology Process of 6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

There total 1 articles about 6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1054483-78-1
2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1346818-25-4
(R)-5-bromo-3-{1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-2-amine

: 1346816-86-1
6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

Guidance literature:: With cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; at 120 ℃; for 3h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1346816-86-1
6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1346820-02-7
tert-butyl 4-[(6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-yl)oxy]piperidine-1-carboxylate

: 1346820-03-8
tert-butyl 4-[6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-6-oxo-(3,3'-bipyridin)-1(6H)-yl]piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; at 90 ℃; for 24h;

Reference yield:

: 1346816-86-1
6'-amino-5'-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-(3,3'-bipyridin)-6-ol

: 1346816-87-2
5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-6'-(piperidin-4-yloxy)-(3,3'-bipyridin)-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 24 h / 90 °C

2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; methanol;