(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Base Information

Chemical Name:(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol
CAS No.:342902-89-0
Molecular Formula:C₂₈H₃₆O₂Si
Molecular Weight:432.678
Hs Code.:

Synonyms:(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Suppliers and Price of (+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

There total 5 articles about (+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 342902-83-4
3,6-dodecadiyne-1,5-diol

: 342902-89-0
(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(00)00495-X

Reference yield:

: 1846-68-0
oct-2-ynal

: 342902-89-0
(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 6 h / -78 - 20 °C

2: 80 percent / PPTS / methanol / 0.75 h / 20 °C

3: 62 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1016/S0957-4166(00)00495-X

Reference yield:

: 110-53-2
1-Bromopentane

: 342902-89-0
(+/-)-1-(4-O-tert-butyldiphenylsilyl-1-butynyl)-2-octynyl alcohol

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LiNH₂; NH₃ / tetrahydrofuran; hexamethylphosphoric acid triamide / 6 h

2: 80 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.58 h / -78 - 25 °C

3: 60 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 6 h / -78 - 20 °C

4: 80 percent / PPTS / methanol / 0.75 h / 20 °C

5: 62 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; n-butyllithium; lithium amide; oxalyl dichloride; ammonia; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; 2: Swern oxidation;
DOI:10.1016/S0957-4166(00)00495-X