(2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

Base Information

• Chemical Name: (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide
• CAS No.: 868127-84-8
• Molecular Formula: C₄₃H₅₄O₈Si
• Molecular Weight: 726.982

Synonyms:(2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

Chemical Property of (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

Chemical Property:

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Technology Process of (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

There total 1 articles about (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3R)-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide (868127-82-6) + 3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide (868127-84-8)

Guidance literature:

(3R)-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -70 ℃;

3-methoxy-4-(phenylmethoxy)benzaldehyde; In tetrahydrofuran; toluene; at -70 ℃; for 1h; Further stages.;

DOI:10.1021/np050089s

Reference yield: 100.0%

(2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide (868127-84-8) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → (2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide (868127-88-2)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1021/np050089s

Reference yield:

(2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(hydroxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide (868127-84-8) → C34H34O8

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1271/bbb.60096

upstream raw materials:

(3R)-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

3-methoxy-4-(phenylmethoxy)benzaldehyde

Downstream raw materials:

(2S,3R)-2-[(S)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-3-[(R)-(4-benzyloxy-3-methoxyphenyl)(triisopropylsilyloxy)methyl]-4-butanolide

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