(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

Base Information

Chemical Name:(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine
CAS No.:874896-15-8
Molecular Formula:C₂₁H₃₁NOS
Molecular Weight:345.549
Hs Code.:

Synonyms:(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

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Technology Process of (1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

There total 7 articles about (1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 745801-38-1
(1S,2R,4R)-1-benzylsulfanylmethyl-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ylamine

: 874896-15-8
(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Heating;
DOI:10.1021/jo052017b

Reference yield:

: 54984-43-9,77026-99-4
(1S,4R)-camphor-10-thiol

: 874896-15-8
(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / sodium methoxide / methanol / 6 h / 20 °C

2: 98 percent / hydroxyl amine hydrochloride; sodium acetate / ethanol; H₂O / 18 h / Heating

3: 74 percent / TiCl₃; sodium acetate; borane-tert-butylamine complex / ethanol / 10 h / 0 °C

4: 77 percent / potassium carbonate / acetonitrile / 12 h / Heating

With titanium(III) chloride; hydroxylamine hydrochloride; sodium methylate; sodium acetate; borane tert-butylamine; potassium carbonate; In methanol; ethanol; water; acetonitrile;
DOI:10.1021/jo052017b

Reference yield:

: 745801-28-9
(1S,4R)-1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one

: 874896-15-8
(1S,4R)-4-{1-[(benzylsulfanyl)methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl}morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / hydroxyl amine hydrochloride; sodium acetate / ethanol; H₂O / 18 h / Heating

2: 74 percent / TiCl₃; sodium acetate; borane-tert-butylamine complex / ethanol / 10 h / 0 °C

3: 77 percent / potassium carbonate / acetonitrile / 12 h / Heating

With titanium(III) chloride; hydroxylamine hydrochloride; sodium acetate; borane tert-butylamine; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1021/jo052017b