1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

Base Information

Chemical Name:1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol
CAS No.:463942-76-9
Molecular Formula:C₄₉H₆₂O₃Si₂
Molecular Weight:755.2
Hs Code.:

Synonyms:1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

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Chemical Property of 1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

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Technology Process of 1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

There total 15 articles about 1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 463942-75-8
1-[1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyloxymethyl]-4-methoxybenzene

: 463942-76-9
1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00423-4

Reference yield:

: 99745-00-3
(2S,3S)-2,3-epoxydecan-1-ol

: 463942-76-9
1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 84 percent / titanium(IV) isopropoxide / toluene / 2 h / Heating

2.1: 88 percent / imidazole / CH₂Cl₂ / 6 h / 20 °C

3.1: 80 percent / triethylamine / CH₂Cl₂ / 48 h / 20 °C

4.1: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: BF₃*OEt₂ / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.3: 75 percent / tetrahydrofuran; hexane / 1 h / -78 °C

6.1: 91 percent / imidazole / CH₂Cl₂ / 6 h / 20 °C

7.1: 94 percent / CuCl₂*2H₂O / acetonitrile / 3 h / 20 °C

8.1: 89 percent / triphenylphosphine; I₂; imidazole / toluene / 3 h / Heating

9.1: 82 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h / 20 °C

With 1H-imidazole; titanium(IV) isopropylate; n-butyllithium; tetrabutyl ammonium fluoride; iodine; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4020(02)00423-4

Reference yield:

: 13039-93-5
2,2:4,5-di-O-isopropylidene-D-arabinose

: 463942-76-9
1-heptyl-2,8-di(tert-butyldiphenylsilyloxy)-(1R,2R,8R)-9-decen-4,6-diynyl-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: triphenylphosphine / CH₂Cl₂ / 0.5 h / -20 °C

1.2: 86 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 82 percent / tetrahydrofuran; hexane / 2.5 h / 20 °C

3.1: 96 percent / carbon tetrachloride; triphenylphosphine; sodium bicarbonate / 4 h / Heating

4.1: 85 percent / lithium amide / tetrahydrofuran; hexamethylphosphoric acid triamide; liquid ammonia / 0.5 h

5.1: 88 percent / imidazole / CH₂Cl₂ / 24 h / 20 °C

6.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: BF₃*OEt₂ / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.3: 75 percent / tetrahydrofuran; hexane / 1 h / -78 °C

7.1: 91 percent / imidazole / CH₂Cl₂ / 6 h / 20 °C

8.1: 94 percent / CuCl₂*2H₂O / acetonitrile / 3 h / 20 °C

9.1: 89 percent / triphenylphosphine; I₂; imidazole / toluene / 3 h / Heating

10.1: 82 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h / 20 °C

With 1H-imidazole; tetrachloromethane; n-butyllithium; lithium amide; iodine; sodium hydrogencarbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; ammonia; water; toluene; acetonitrile;
DOI:10.1016/S0040-4020(02)00423-4