Technology Process of tricyclo<3.3.1.13,7>dec-2-yl *,S*(E)>>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,12-trioxo-6-(phenylmethyl)-13-oxa-2,5,8-triazatetradec-10-enoate
There total 9 articles about tricyclo<3.3.1.13,7>dec-2-yl *,S*(E)>>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,12-trioxo-6-(phenylmethyl)-13-oxa-2,5,8-triazatetradec-10-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 89 percent / Et3N / tetrahydrofuran / 0.25 h
3: 90 percent / LiOH / H2O; dioxane / 18 h / Ambient temperature
4: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h
5: 95 percent / AcOH, H2 / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr
6: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 3 h, 2.) RT, 18 h
With
pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1021/jm00105a062
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / HN3, Ph3P, (i-PrO2CN)2 / tetrahydrofuran; toluene / 1 h / Ambient temperature
2: 86 percent / LiOH, H2O / dioxane / 18 h / Ambient temperature
3: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h
4: 95 percent / AcOH, H2 / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr
5: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 3 h, 2.) RT, 18 h
With
lithium hydroxide; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; 2,3,4,5,6-pentafluorophenol; water; hydrogen; acetic acid; dicyclohexyl-carbodiimide; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; toluene;
DOI:10.1021/jm00105a062
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Et3N / tetrahydrofuran / 0.25 h
2: 90 percent / LiOH / H2O; dioxane / 18 h / Ambient temperature
3: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h
4: 95 percent / AcOH, H2 / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr
5: 1.) C6F5OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 3 h, 2.) RT, 18 h
With
lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1021/jm00105a062
