diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

Base Information

Chemical Name:diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate
CAS No.:179999-12-3
Molecular Formula:C₃₇H₃₆N₄O₁₅S
Molecular Weight:808.777
Hs Code.:

Synonyms:diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

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Chemical Property of diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

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Technology Process of diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

There total 3 articles about diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16115-68-7
diethyl L-aspartate hydrochloride

: 179999-12-3
diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / Et₃N / dimethylformamide / 16 h

2: 1.) chlorotrimethylsilane, hexamethyldisilazane, 2.) trimethylsilyl trifluoromethanesulfonate / 1.) xylene, 130 deg C, 90 min, 2.) acetonitrile, RT, 16 h

With chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00472-3

Reference yield:

: 13552-87-9
L-aspartic acid diethyl ester

: 179999-12-3
diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide

2: 1.) TMSCl, HMDS, 2.) TMSOTf / 1.) xylene, reflux, 2 h, 2.) xylene, MeCN, 0 deg C to room temp., 16 h

With chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(94)85344-4

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 161359-34-8
diethyl N-<4(5)-nitroimidazole-5(4)-sulphonyl>-L-aspartate

: 161359-35-9
diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

: 179999-12-3
diethyl N-<4-nitro-1-(2,3,5-tri-O-benzoyl-α-D-ribofuranosyl)imidazole-5-sulfonyl>-L-aspartate

Guidance literature:: With chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction. Yields of byproduct given; 1.) xylene, 130 deg C, 90 min, 2.) acetonitrile, RT, 16 h;
DOI:10.1016/0040-4020(96)00472-3