2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone

Base Information

Chemical Name:2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone
CAS No.:796067-49-7
Molecular Formula:C₁₄H₁₉ClN₂O
Molecular Weight:266.771
Hs Code.:
DSSTox Substance ID:DTXSID101181993
Wikidata:Q27193455
ChEMBL ID:CHEMBL1581233

Synonyms:796067-49-7;2-chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone;2-chloro-1-{4-[(3-methylphenyl)methyl]piperazin-1-yl}ethan-1-one;SMR000253950;MLS000336096;2-chloro-1-[4-[(3-methylphenyl)methyl]piperazin-1-yl]ethanone;SR-01000061392;1-(chloroacetyl)-4-(3-methylbenzyl)piperazine;CHEMBL1581233;BDBM54258;cid_2454965;CHEBI:112991;DTXSID101181993;HMS2516M17;HMS3377B09;AKOS022189417;PD194673;EN300-11568;2-chloro-1-[4-(3-methylbenzyl)piperazino]ethanone;SR-01000061392-1;SR-01000061392-3;Q27193455;Z57052860;2-chloranyl-1-[4-[(3-methylphenyl)methyl]piperazin-1-yl]ethanone

Suppliers and Price of 2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:266.1185909
Heavy Atom Count:18
Complexity:277

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)CN2CCN(CC2)C(=O)CCl

Technology Process of 2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone

There total 2 articles about 2-Chloro-1-[4-[(3-methylphenyl)methyl]-1-piperazinyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 5321-48-2
1-(3-methylbenzyl)piperazine

: 79-04-9
chloroacetyl chloride

: 796067-49-7
2-chloro-1-(4-(3-methylbenzyl)piperazin-1-yl)ethanone

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.01.020

Reference yield:

: 620-19-9
1-chloromethyl-3-methyl-benzene

: 796067-49-7
2-chloro-1-(4-(3-methylbenzyl)piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 4 h / Reflux

2: dichloromethane / 0 - 20 °C

In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.01.020