Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

Base Information

Chemical Name:Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester
CAS No.:263887-35-0
Molecular Formula:C₁₄H₁₉IO₇S
Molecular Weight:458.271
Hs Code.:

Synonyms:Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

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Chemical Property of Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

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Technology Process of Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

There total 3 articles about Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 107-30-2
chloromethyl methyl ether

: 237736-54-8
(E)-3-(5-hydroxy-3-iodo-4-mesyloxyphenyl)-2-propen-1-ol

: 263887-35-0
Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16.5h;
DOI:10.3987/com-99-s63

Reference yield:

: 263887-34-9
(E)-3-(3-Hydroxy-5-iodo-4-methanesulfonyloxy-phenyl)-acrylic acid ethyl ester

: 263887-35-0
Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / DIBALH / tetrahydrofuran; toluene / 4 h / -78 °C

2: 79 percent / i-Pr₂NEt / dimethylformamide / 16.5 h / 20 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: Reduction / 2: Etherification;
DOI:10.3987/com-99-s63

Reference yield:

: 172515-98-9
(E)-3-(3-Iodo-4-methanesulfonyloxy-5-methoxy-phenyl)-acrylic acid ethyl ester

: 263887-35-0
Methanesulfonic acid 2-iodo-6-methoxymethoxy-4-((E)-3-methoxymethoxy-propenyl)-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / BBr₃ / CHCl₃ / 52 h / 0 °C

2: 99 percent / DIBALH / tetrahydrofuran; toluene / 4 h / -78 °C

3: 79 percent / i-Pr₂NEt / dimethylformamide / 16.5 h / 20 °C

With boron tribromide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Reduction / 3: Etherification;
DOI:10.3987/com-99-s63