2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1312018-12-4
Molecular Formula:C₂₇H₃₄N₂O₄S
Molecular Weight:482.644
Hs Code.:

Synonyms:2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

There total 17 articles about 2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

: 1312018-11-3
2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-vinyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

: 1312018-12-4
2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 50 ℃; for 8h; under 37503.8 Torr; Product distribution / selectivity;

Reference yield:

: 1312018-08-8
1-[1-benzenesulfonyl-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-cyclopentyl-ethanone

: 1312018-12-4
2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 50 °C / 37503.8 Torr

With tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 271-63-6
7-Azaindole

: 1312018-12-4
2-[2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 14 steps

1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

5.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

5.2: 12.25 h / 0 - 25 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 20 - 80 °C

7.1: 1,4-bis(9-O-dihydroquinidine)phthalazine; methanesulfonamide / water; tert-butyl alcohol / 12 h / 0 °C

7.2: 0.5 h / 25 °C

8.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 25 °C

9.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

9.2: 1 h / -78 °C

10.1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

11.2: 1.5 h / -78 °C

12.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation

13.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

14.1: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 50 °C / 37503.8 Torr

With pyridine; formic acid; methanesulfonamide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; bromine; sodium hydride; sodium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;