2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone

Base Information

• Chemical Name: 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone
• CAS No.: 503072-83-1
• Molecular Formula: C₁₈H₁₉FN₄O₃S
• Molecular Weight: 390.438

Synonyms:2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone

Chemical Property of 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone

There total 3 articles about 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(4-fluorophenyl)acetyl]-4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester (660857-92-1) → 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone (503072-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: NaOH / CH₂Cl₂; H₂O

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

4-Fluorophenylacetyl chloride (459-04-1) → 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone (503072-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / CH₂Cl₂; H₂O

2: H₂ / Pd/C / methanol

3: NaOH / CH₂Cl₂; H₂O

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2004.06.001

Reference yield:

2-(methylsulfanyl)pyrimidine-4-carbonyl chloride (503177-82-0) + 2-(4-fluorophenyl)-1-(4-methoxy-pyrazolidin-1-yl)-ethanone (503072-82-0) → 2-(4-fluorophenyl)-1-[4-methoxy-2-(2-methylsulfanyl-pyrimidine-4-carbonyl)pyrazolidine-1-yl]-ethanone (503072-83-1)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.bmcl.2004.06.001

upstream raw materials:

2-(methylsulfanyl)pyrimidine-4-carbonyl chloride

2-(4-fluorophenyl)-1-(4-methoxy-pyrazolidin-1-yl)-ethanone

4-Fluorophenylacetyl chloride

2-[2-(4-fluorophenyl)acetyl]-4-methoxy-pyrazolidine-1-carboxylic acid benzyl ester

Downstream raw materials:

2-(4-fluorophenyl)-6-methoxy-3-(2-methanesulfonyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one

2-(4-fluorophenyl)-6-methoxy-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one

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