Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

Base Information

Chemical Name:Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester
CAS No.:203250-01-5
Molecular Formula:C₂₄H₃₆O₈S₂Si
Molecular Weight:544.763
Hs Code.:

Synonyms:Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

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Chemical Property of Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

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Technology Process of Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

There total 4 articles about Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 203250-00-4
(R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-(2-hydroxy-ethoxy)-butan-1-ol

: 203250-01-5
Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

Guidance literature:: With triethylamine; In diethyl ether; at 5 ℃; for 1.5h;
DOI:10.1021/jo971980h

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 203250-01-5
Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) borane-methyl sulfide complex, NaBH₄, 2.) imidazole / 1.) THF, 0 deg C, 2.) CH₂Cl₂

2: 1.) trifluoromethanesulfonic acid, 2.) diisobutylaluminum hydride / 1.) cyclohexane, room temperature, 2.5 d, 2.) THF, toluene, -78 -> -5 deg C

3: 1.) ozone, 2.) NaBH₄ / 1.) methanol, -78 deg C, 20 min, 2.) methanol

4: 99 percent / triethylamine / diethyl ether / 1.5 h / 5 °C

With 1H-imidazole; sodium tetrahydroborate; trifluorormethanesulfonic acid; dimethylsulfide borane complex; diisobutylaluminium hydride; ozone; triethylamine; In diethyl ether;
DOI:10.1021/jo971980h

Reference yield:

: 159801-08-8
methyl (3R)-4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

: 203250-01-5
Methanesulfonic acid (R)-4-(tert-butyl-diphenyl-silanyloxy)-3-(2-methanesulfonyloxy-ethoxy)-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) trifluoromethanesulfonic acid, 2.) diisobutylaluminum hydride / 1.) cyclohexane, room temperature, 2.5 d, 2.) THF, toluene, -78 -> -5 deg C

2: 1.) ozone, 2.) NaBH₄ / 1.) methanol, -78 deg C, 20 min, 2.) methanol

3: 99 percent / triethylamine / diethyl ether / 1.5 h / 5 °C

With sodium tetrahydroborate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; ozone; triethylamine; In diethyl ether;
DOI:10.1021/jo971980h