(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

Base Information

Chemical Name:(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne
CAS No.:532437-80-2
Molecular Formula:C₂₆H₃₆O₅
Molecular Weight:428.569
Hs Code.:

Synonyms:(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

Suppliers and Price of (3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

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Chemical Property of (3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

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Technology Process of (3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

There total 10 articles about (3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 532437-78-8
(3S,7S,9R)-9-benzyloxy-7-hydroxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

: 532437-80-2
(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 3h;
DOI:10.1016/S0957-4166(03)00040-5

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 532437-80-2
(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / p-TsOH*H₂O / CH₂Cl₂ / 3 h / 23 °C

2.1: nBuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 87 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 2 h / -78 °C

3.1: 94 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h

With dmap; n-butyllithium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0957-4166(03)00040-5

Reference yield:

: 532437-63-1
(2R,4R)-4-benzyloxy-1,2-epoxypentane

: 532437-80-2
(3S,7S,9R)-7-acetoxy-9-benzyloxy-1,3-O-cyclohexylidene-3-methyldec-4-yne

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 87 percent / BF₃*OEt₂ / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 94 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0957-4166(03)00040-5