2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide

Base Information

• Chemical Name: 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide
• CAS No.: 1375502-47-8
• Molecular Formula: C₂₀H₂₁ClN₆O
• Molecular Weight: 396.879
• Mol file: 1375502-47-8.mol

Synonyms:2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide

Chemical Property of 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide

There total 3 articles about 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(4-chlorophenyl) piperazine (38212-33-8) + 2-chloro-N'-(phthalazin-1-yl)acetohydrazide (1375502-41-2) → 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide (1375502-47-8)

Guidance literature:

With triethylamine; In acetonitrile; for 3h; Reflux;

DOI:10.1016/j.ejmech.2012.02.051

Reference yield:

1-hydrazinophthalazine (1044569-46-1) → 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide (1375502-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / Reflux

2: triethylamine / acetonitrile / 3 h / Reflux

With triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2012.02.051

Reference yield:

o-carboxybenzaldehyde (119-67-5) → 2-(4-(4-chlorophenyl)piperazin-1-yl)-N'-(phthalazin-1-yl)acetohydrazide (1375502-47-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine hydrate / 1 h

2: trichlorophosphate / 0.03 h

3: hydrazine hydrate / ethanol / 1 h

4: dichloromethane / 1 h / Reflux

5: triethylamine / acetonitrile / 3 h / Reflux

With hydrazine hydrate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2012.02.051

upstream raw materials:

1-hydrazinophthalazine

4-(4-chlorophenyl) piperazine

2-chloro-N'-(phthalazin-1-yl)acetohydrazide

o-carboxybenzaldehyde