1044569-46-1

Basic information

• Product Name: Ophthazin Impurity 2
• Synonyms: Ophthazin Impurity 2
• CAS NO: 1044569-46-1
• Molecular Weight: 160.178
• Mol File: 1044569-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ophthazin Impurity 2(CAS DataBase Reference)
• NIST Chemistry Reference: Ophthazin Impurity 2(1044569-46-1)
• EPA Substance Registry System: Ophthazin Impurity 2(1044569-46-1)

Safety Data

• Hazardous Substances Data: 1044569-46-1(Hazardous Substances Data)

Usage

General Description

Ophthazin Impurity 2 is a chemical impurity that is commonly found in ophthalmic products. It is categorized as a potential impurity in drugs and pharmaceuticals and is included in the list of impurities that need to be monitored and controlled during the manufacturing process. Ophthazin Impurity 2 is known to have potential adverse effects on the human body, and therefore, strict regulations and guidelines are in place to limit its presence in pharmaceutical products. It is essential for manufacturers and regulatory authorities to closely monitor and control the levels of Ophthazin Impurity 2 in order to ensure the safety and efficacy of ophthalmic products.

Downstream Products

• 3778-76-5 todralazine hydrochloride 
• 70591-70-7 3-phenyl-s-triazolo[3,4-a]phthalazine 
• 67536-13-4 hydralazine pyruvic acid hydrazone 
• 21517-09-9 s-Triazolo(3,4-a)phthalazin-3H-3-on 
• 24030-07-7 1,1'-diazane-1,2-diyl-bis-phthalazine 
• 88-36-8 6-chloro-1,1-dioxo-3-(2-phthalazin-1-ylhydrazono-propyl)-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 
• 79480-21-0 1-[5-(4-Methoxy-phenyl)-3-phenyl-pyrazol-1-yl]-phthalazine 
• 79480-19-6 5-Benzyl-4-phenyl-1-(1'-phthalazinyl)pyrazole 
• 132577-11-8 4-[(3-Methoxy-phenyl)-hydrazono]-5-methyl-2-phthalazin-1-yl-2,4-dihydro-pyrazol-3-one 
• 20062-41-3 3-methyl-s-triazolo<3,4-a>phthalazine 
• 141-78-6 ethyl acetate 
• 112382-02-2 3-Chloro-benzoic acid N'-phthalazin-1-yl-hydrazide; hydrochloride 
• 88330-85-2 ethyl β-(1-phthalazinylhydrazino)benzenepropanoate 
• 132577-20-9 4-[(4-Hydroxy-phenyl)-hydrazono]-5-methyl-2-phthalazin-1-yl-2,4-dihydro-pyrazol-3-one 

Relevant articles and documents

Kinetic study of the reaction of pyridoxal 5'-phosphate with hydrazino compounds of pharmacological activity

The kinetics of the reaction between pyridoxal 5'-phosphate (PLP) with carbidopa, hydralazine, and isoniazid, in aqueous solution at variable pH and constant ionic strength of 0.1M was studied spectrophotometrically. The rate constants of formation and hydrolysis of the resulting Schiff base, and its stability were determined in a wide range of pH. A comparison is made of the formation rate constants with those of PLP with hydrazine. The reactivity shows the sequence isoniazid > hydrazine > carbidopa > hydralazine in the whole range of pH studied. The Schiff bases studied are more stable than those formed by PLP and hexylamine and as stable as those described for the reactions of PLP with poly(L-lysine) or copolypeptides containing L-lysine.