(3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone

Base Information

• Chemical Name: (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone
• CAS No.: 104485-43-0
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293

Synonyms:(3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone

Chemical Property of (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

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Technology Process of (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone

There total 5 articles about (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3S,4S)-4-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-((R)-1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one (172944-57-9) → (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone (104485-43-0)

Guidance literature:

With trifluorormethanesulfonic acid; In butanone;

DOI:10.1246/cl.1995.1013

Reference yield: 85.0%

(2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide → (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone (104485-43-0)

Guidance literature:

With titanium tetrachloride; diisopropylamine; In dichloromethane; at -30 ℃; for 0.5h;

Reference yield:

(2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide → C14H17NO4 + C14H17NO4 + (3S,4S)-1-(4-methoxyphenyl)-3-[((R)-1-hydroxyethyl)]-4-acetyl-2-azetidinone (104485-43-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

upstream raw materials:

(3S,4S)-4-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-((R)-1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one

(4S)-4-<(4S,5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolan-2-yl>-1-p-methoxyphenyl-2-azetidinone

Downstream raw materials:

(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

(E)-4-[(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-penta-2,4-dienoic acid ethyl ester

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