(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Base Information

Chemical Name:(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one
CAS No.:104401-80-1
Molecular Formula:C₂₀H₃₁NO₄Si
Molecular Weight:377.556
Hs Code.:

Synonyms:(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of (3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

There total 6 articles about (3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 75-16-1
methylmagnesium bromide

: 113396-67-1
(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carboxylic acid methoxy-methyl-amide

: 104401-80-1
(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)95993-8

Reference yield:

: (2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 104401-80-1
(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: (2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

tert-butyldimethylsilyl chloride; With dmap; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: (2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: C₂₀H₃₁NO₄Si

: 104401-80-1
(3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one

Guidance literature:: (2R,3R)-N-(4-methoxyphenyl)-N-(2-oxopropyl)-2,3-epoxybutylamide; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 12h;

tert-butyldimethylsilyl chloride; With dmap; In N,N-dimethyl-formamide; at 50 ℃; for 16h;