tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate
CAS No.:1374041-07-2
Molecular Formula:C₃₁H₃₈N₂O₅Si
Molecular Weight:546.739
Hs Code.:

Synonyms:tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

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Chemical Property of tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

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Technology Process of tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

There total 4 articles about tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23308-83-0
(2-nitrobenzyl)triphenylphosphonium bromide

: 254763-27-4
tert-butyl N-[(1R)-1-[[tert-butyl(diphenyl)silyl]oxymethyl]-2-oxo-ethyl]carbamate

: 1374041-07-2
tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

Guidance literature:: (2-nitrobenzyl)triphenylphosphonium bromide; tert-butyl N-[(1R)-1-[[tert-butyl(diphenyl)silyl]oxymethyl]-2-oxo-ethyl]carbamate; In 1,2-dimethoxyethane; at 20 ℃; for 0.5h; Inert atmosphere;

With 18-crown-6 ether; potassium carbonate; In 1,2-dimethoxyethane; at 20 ℃; for 14h; Inert atmosphere;

Reference yield:

: 167102-61-6
tert-butyl N-[(1R)-1-(hydroxymethyl)-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate

: 1374041-07-2
tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 17 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 14 h / 20 °C / Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2
(R)-N-tert-butoxycarbonyl serine

: 1374041-07-2
tert-butyl [(2S,3E)-1-{[tert-butyl(diphenyl)silyl]oxy}-4-(2-nitrophenyl)but-3-en-2-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 2.17 h / -15 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 17 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

4.1: 1,2-dimethoxyethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 14 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1H-imidazole; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;