23308-83-0

Basic information

• Product Name: (2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE
• Synonyms: (2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE;(2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDRATE;(2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE;(2-Nitrobenzyl)triphenylphosphonium Brmide;(2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE, 98+;Nsc226219
• CAS NO: 23308-83-0
• Molecular Formula: Br*C₂₅H₂₁NO₂P
• Molecular Weight: 496.33
• Mol File: 23308-83-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 238-240°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• BRN: 4086172
• CAS DataBase Reference: (2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE(23308-83-0)
• EPA Substance Registry System: (2-NITROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE MONOHYDRATE(23308-83-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 23308-83-0(Hazardous Substances Data)

Usage

General Description

(2-Nitrobenzyl)triphenylphosphonium bromide monohydrate is a chemical compound that consists of a triphenylphosphonium cation and a nitrobenzyl anion, with a bromide ion and a water molecule as counter ions. It is a quaternary ammonium salt and is commonly used as a phase-transfer catalyst in organic synthesis. The compound is often employed in reactions that involve the transfer of an anion from one phase to another, and it facilitates the conversion of reactants into products by increasing their solubility in the reaction medium. Additionally, (2-Nitrobenzyl)triphenylphosphonium bromide monohydrate has been utilized in the synthesis of various biologically active compounds and pharmaceuticals.

InChI:InChI=1/C25H21NO2P.BrH.H2O/c27-26(28)25-19-11-10-12-21(25)20-29(22-13-4-1-5-14-22,23-15-6-2-7-16-23)24-17-8-3-9-18-24;;/h1-19H,20H2;1H;1H2/q+1;;/p-1

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 603-35-0 triphenylphosphine 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 81564-46-7 cis-2-<2-(2-nitrophenyl)vinyl>furan 
• 54648-30-5 trans-2-<2-(2-nitrophenyl)vinyl>furan 
• 81564-47-8 cis-2-methyl-5-<2-(2-nitrophenyl)vinyl>furan 
• 81564-48-9 trans-2-methyl-5-<2-(2-nitrophenyl)vinyl>furan 
• 88-72-2 1-methyl-2-nitrobenzene 
• 76916-64-8 1-(2-nitrophenyl)-1,5-hexadiene 
• 81265-90-9 2-(4-fluorophenyl)–2H-indazole 
• 57707-15-0 ethyl 4-(2H-indazol-2-yl)benzoate 
• 223379-59-7 (E)-2-Amino-2'-bromostilbene 
• 243-38-9 6H-quinindoline 
• 223379-82-6 6-tosyl-6H-indolo[2,3-b]quinoline 
• 223379-71-3 N-[3-(2-Bromo-phenyl)-quinolin-2-yl]-4-methyl-benzenesulfonamide 
• 223379-66-6 (E)-2-Bromo-2'-(triphenylphosphoranylidene)aminostilbene 
• 80556-69-0 bromure d'o-acetylaminobenzyltriphenyl-phosphonium 

Relevant articles and documents

Functionalized Cyclopropanes as Versatile Intermediates for the Diversity-Oriented Synthesis of γ-Lactones, γ-Lactams and δ-Lactams

A two-step procedure for the preparation of cyclopropanecarboxaldehyde-1,1-diester from a γ,δ-epoxyester and its synthetic versatility are described herein. The epoxide ring-opening/cyclopropanation process occurs in the presence of Mg(ClO 4) 2under heating, resulting in cyclopropanemethanol-1,1-diester in 65% yield. A mild TEMPO-mediated oxidation of this substrate readily generated the corresponding aldehyde in 75% yield, which was applied in the one-pot synthesis of four cyclopropylidene-γ-lactams and three δ-lactams. In addition, vinylcyclopropanes were obtained through the Wittig reaction of the aldehyde with phosphonium salts and used as precursors for tetrahydrofurans.

Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility

LXRβ-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. We have reported a series of tetrachlorophthalimide analogs as an LXRβ-selective agonist. However, they exhibited poor aqueous solubility probably due to its high hydrophobicity and highly rigid and plane structure. In this report, we present further structural development of tetrachloro(styrylphenyl)phthalimides as the LXRβ-selective agonists with improved aqueous solubility.

Novel composite phosphonium salt as well as preparation method and antibacterial application thereof

The invention belongs to the technical field of fine chemical synthesis and particularly relates to a novel composite phosphonium salt as well as a preparation method and an antibacterial application thereof. The novel composite phosphonium salt adopts a