7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Name:7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497851-47-5
Molecular Formula:C₃₇H₃₅ClF₃N₃O₆
Molecular Weight:710.15
Hs Code.:

7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Synonyms:7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Chemical Property of 7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Technology Process of 7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 8 articles about 7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 497854-62-3
7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(pyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

: 497851-47-5
7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.52.818

Reference yield:

: 5568-33-2
2-chloro-4-nitrobenzaldehyde

: 497851-47-5
7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 30 percent / diethyl ether; hexane; tetrahydrofuran / -78 °C

2.1: 24 percent / Na₂S₂O₄ / tetrahydrofuran; ethanol; H₂O / 0.5 h / 20 °C

3.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

3.2: 31 percent / Et₃N / dimethylformamide / 20 °C

4.1: 63 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

With n-butyllithium; sodium dithionite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.52.818

Reference yield:

: 52301-88-9
(2-chloro-4-nitrophenyl)methanol

: 497851-47-5
7-[4-(2-butoxyethoxy)phenyl]-N-{3-chloro-4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 12.1 g / MnO₂ / acetone / 20 °C

2.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

2.2: 30 percent / diethyl ether; hexane; tetrahydrofuran / -78 °C

3.1: 24 percent / Na₂S₂O₄ / tetrahydrofuran; ethanol; H₂O / 0.5 h / 20 °C

4.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

4.2: 31 percent / Et₃N / dimethylformamide / 20 °C

5.1: 63 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; n-butyllithium; sodium dithionite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.52.818