3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

Base Information

Chemical Name:3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione
CAS No.:1272379-56-2
Molecular Formula:C₂₂H₂₆ClN₅O₂
Molecular Weight:427.934
Hs Code.:

Synonyms:3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

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Chemical Property of 3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

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Technology Process of 3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

There total 3 articles about 3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

: 1233944-05-2
3-amino-1-oxo-2-phenyl-5-(pyrrolidin-1-yl)-1,2,4a,5,6,7,8,9-octahydropyrimido[1,6-a]azepine-4-carbonitrile

: 79-04-9
chloroacetyl chloride

: 1272379-56-2
3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

Guidance literature:: With triethylamine; In benzene; at 70 ℃; for 2h;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: C₂₀H₂₅N₅O

: 1272379-56-2
3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol

2: triethylamine / benzene / 2 h / 70 °C

With sodium tetrahydroborate; triethylamine; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: C₁₆H₁₇ClN₄O

: 1272379-56-2
3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol

2: sodium tetrahydroborate / ethanol

3: triethylamine / benzene / 2 h / 70 °C

With sodium tetrahydroborate; triethylamine; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5