(Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

Base Information

• Chemical Name: (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene
• CAS No.: 729613-11-0
• Molecular Formula: C₈H₅Br₂F
• Molecular Weight: 279.934
• Mol file: 729613-11-0.mol

Synonyms:(Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

Chemical Property of (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

There total 3 articles about (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromo-4-(2-bromo-2-fluorovinyl)benzene + ethyl vinyl ether (109-92-2,25104-37-4) → (Z)-3-fluoro-4-(4-bromophenyl)but-3-en-2-one + (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene (729613-11-0)

Guidance literature:

ethyl vinyl ether; With n-butyllithium; potassium tert-butylate; zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.666667h;

1-bromo-4-(2-bromo-2-fluorovinyl)benzene; With triphenylphosphine; palladium diacetate; In tetrahydrofuran; hexane; at 10 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃; for 0.25h;

DOI:10.1021/jo0604787

Reference yield:

tribromofluoromethane (353-54-8) + 4-bromo-benzaldehyde (1122-91-4) → (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene (729613-11-0) + (E)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

Guidance literature:

With diethylzinc; triphenylphosphine; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h; Title compound not separated from byproducts;

DOI:10.1021/ol049742d

Reference yield:

tribromofluoromethane (353-54-8) + hydrazone of p-bromobenzaldehyde (57477-93-7) → (Z)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene (729613-11-0) + (E)-1-bromo-4-(2-bromo-2-fluorovinyl)benzene

Guidance literature:

With ethylenediamine; copper(l) chloride; In ethanol; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1070/MC2006v016n03ABEH002282

upstream raw materials:

tribromofluoromethane

4-bromo-benzaldehyde

ethyl vinyl ether

hydrazone of p-bromobenzaldehyde