353-54-8

Basic information

• Product Name: FLUOROTRIBROMOMETHANE
• Synonyms: FC-11B3;FLUOROTRIBROMOMETHANE;HALON 1103;TRIBROMOFLUOROMETHANE;CFBr3;tribromofluoro-methan;Fluorotribromomethane (FC-11B3);Fluorotribromomethane,99%
• CAS NO: 353-54-8
• Molecular Formula: CBr3F
• Molecular Weight: 270.72
• EINECS: 206-535-8
• Mol File: 353-54-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: −73.6 °C(lit.)
• Boiling Point: 106-107 °C(lit.)
• Flash Point: 106-107°C
• Appearance: clear colorless liquid
• Density: 2.765 g/mL at 25 °C(lit.)
• Vapor Pressure: 37.1mmHg at 25°C
• Refractive Index: n20/D 1.525(lit.)
• Water Solubility: 399.8mg/L(25 oC)
• BRN: 1732796
• CAS DataBase Reference: FLUOROTRIBROMOMETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: FLUOROTRIBROMOMETHANE(353-54-8)
• EPA Substance Registry System: FLUOROTRIBROMOMETHANE(353-54-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3082 9 / PGIII
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT, OZONE DEPLETER
• Hazardous Substances Data: 353-54-8(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

Tribromofluoromethane (fluorotribromomethane) was used in the synthesis of dibromofluoromethyllithium that reacted with an aldehyde or ketone to give fluorinated alcohol.

InChI:InChI=1/CBr3F/c2-1(3,4)5

Upstream product

• 1133087-04-3 5-allyl-4'-(allyloxy)-2-methoxybiphenyl 
• 68592-15-4 methylhonokiol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 578-57-4 2-bromoanisole 
• 167851-45-8 8-(2-methoxyphenyl)-1,4-dioxa-spiro[4.5]decan-8-ol 
• 911812-86-7 2,4'-bis-O-allylbiphenyl 
• 128-39-2 2,6-di-tert-butylphenol 
• 96-76-4 2,4-di-tert-Butylphenol 
• 14328-91-7 3,3’,5,5’-tetra-tert-butyl-[1,1‘-biphenyl]-2,4’-diol 
• 909865-47-0 3’,5-dibromo-2,4’-dimethoxy-1,1’-biphenyl 
• 2219-82-1 2-tert-Butyl-6-methylphenol 
• 2409-55-4 2-tert-Butyl-4-methylphenol 
• 106-41-2 4-bromo-phenol 
• 25458-45-1 p-methoxymethoxybromobenzene 

Downstream Products

• 392-56-3 Hexafluorobenzene 
• 594-79-6 1,2-difluorotetrabromoethane 
• 344-04-7 bromopentafluorobenzene 
• 75-61-6 dibromodifluoromethane 
• 171503-39-2 1,1-dibromo-1-fluoro-4-phenyl-2-butanol 
• 220115-85-5 1,1-dibromo-1-fluoro-3-methyl-2-butanol 
• 172750-23-1 2,2-dibromo-2-fluoro-1-cyclohexylethanol 
• 402490-63-5 1-((E)-2-Bromo-2-fluoro-vinyl)-4-methoxymethoxy-benzene 
• 402490-59-9 1-((E)-2-Bromo-2-fluoro-vinyl)-3,5-dimethoxy-benzene 
• 402490-61-3 3,5-di-[(methoxymethyl)oxy]-β-bromo-β-fluorostyrene 
• 402490-64-6 1-(2-bromo-2-fluorovinyl)-4-nitrobenzene 
• 1959-48-4 (2-bromo-2-fluoroethene-1,1-diyl)dibenzene 
• 459132-89-9 1-bromo-1-fluoro-2-(4-fluorophenyl)-ethylene 
• 459132-90-2 (E/Z)-1-(2-bromo-2-fluorovinyl)-3-nitrobenzene 

Relevant articles and documents

Gram Scale Synthesis of Honokiol

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Concise and practical approach for the synthesis of honokiol, a neurotrophic agent

An improved method has been developed for the synthesis of honokiol using a readily available p-bromophenol as a precursor. The key step involved in this method is ortho-lithiation facilitated by methoxymethyl ether (MOM). Other important steps are ortho-allyl phenyl ether Claisen rearrangement and a Suzuki coupling for the construction of biaryls. This method does not require pre-functionalization of aromatic ring with bromide for the generation of arylboronic acid.

SYNTHESIS OF HONOKIOL

Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.