4-CHLORO-2-METHOXYBENZALDEHYDE

Base Information

• Chemical Name: 4-CHLORO-2-METHOXYBENZALDEHYDE
• CAS No.: 53581-86-5
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.595
• Hs Code.: 2913000090
• Mol file: 53581-86-5.mol

Synonyms:4-CHLORO-2-METHOXYBENZALDEHYDE

Chemical Property of 4-CHLORO-2-METHOXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 70-75°C
• Refractive Index: 1.564
• Boiling Point: 268.829°C at 760 mmHg
• Flash Point: 120.526°C
• PSA: 26.30000
• Density: 1.245g/cm³
• LogP: 2.16110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

4-Chloro-2-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-METHOXYBENZALDEHYDE

There total 13 articles about 4-CHLORO-2-METHOXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-5-chloroanisole (174913-09-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-2-methoxybenzaldehyde (53581-86-5)

Guidance literature:

2-bromo-5-chloroanisole; With n-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; Inert atmosphere; Flow reactor;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -30 ℃; Inert atmosphere; Flow reactor;

DOI:10.1021/acs.orglett.6b01681

Reference yield: 95.0%

(4-chloro-2-methoxy-phenyl)methanol (90296-27-8) → 4-chloro-2-methoxybenzaldehyde (53581-86-5)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.200900389

Reference yield: 80.0%

4-chlorosalicylaldehyde (2420-26-0) + dimethyl sulfate (77-78-1) → 4-chloro-2-methoxybenzaldehyde (53581-86-5)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Reflux;

DOI:10.1021/acs.joc.7b02630

upstream raw materials:

4-chlorosalicylaldehyde

dimethyl sulfate

(4-chloro-2-methoxy-phenyl)methanol

3-monochlorophenol

Downstream raw materials:

2-methoxy-4-chlorobenzoic acid

4,4'-dichloro-2,2'-dimethoxy-benzoin

4-Chlor-2-methoxyphenylisopropylamin

1-Hydroxy-2-(4-chloro-2-methoxyphenyl)-4-methyl-5-(3-pyridyl)imidazole

Refernces

• 1、 Zhang, Xiao,King-Smith, Emma,Renata, Hans. "Total Synthesis of Tambromycin by Combining Chemocatalytic and Biocatalytic C?H Functionalization". supporting information. p. 5037 - 5041. Retrieved 2018/03/27.
• 2、 Hafner, Andreas,Meisenbach, Mark,Sedelmeier, Joerg. "Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s". supporting information. p. 3630 - 3633. Retrieved 2016/08/16.