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CAS No.: | 53581-86-5 |
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Name: | 4-CHLORO-2-METHOXYBENZALDEHYDE |
Article Data: | 16 |
Molecular Structure: | |
Formula: | C8H7ClO2 |
Molecular Weight: | 170.595 |
Synonyms: | 4-CHLORO-2-METHOXYBENZALDEHYDE |
Density: | 1.245g/cm3 |
Melting Point: | 70-75°C |
Boiling Point: | 268.829°C at 760 mmHg |
Flash Point: | 120.526°C |
Hazard Symbols: | Xn |
Risk Codes: | 20/21/22 |
PSA: | 26.30000 |
LogP: | 2.16110 |
2-bromo-5-chloroanisole
N,N-dimethyl-formamide
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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Stage #1: 2-bromo-5-chloroanisole With n-butyllithium In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor; | 97% |
(4-chloro-2-methoxy-phenyl)methanol
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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With manganese(IV) oxide In chloroform for 2h; Inert atmosphere; Reflux; | 95% |
Stage #1: (4-chloro-2-methoxy-phenyl)methanol With Chloro-oxo-acetic acid; dimethyl sulfoxide In dichloromethane at -78 - -40℃; for 1h; Swern oxidation; Stage #2: With triethylamine at 20℃; for 0.25h; Swern oxidation; | 65% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; iodine; sodium hydrogencarbonate In water; toluene at 20℃; for 72h; | |
With manganese(IV) oxide In dichloromethane at 20℃; for 18h; | 400 mg |
Stage #1: (4-chloro-2-methoxy-phenyl)methanol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 0.5h; Swern Oxidation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at -78 - 20℃; for 16h; Swern Oxidation; Inert atmosphere; |
Conditions | Yield |
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With potassium carbonate In acetone for 12h; Reflux; | 80% |
4-chloro-2-fluorobenzaldehyde
sodium methylate
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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With methanol at 50℃; for 3h; | 77.5% |
In methanol Reflux; |
Conditions | Yield |
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With sodium carbonate at 65℃; for 3h; | 51% |
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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With hydrogenchloride; copper |
3-monochlorophenol
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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Multi-step reaction with 2 steps 1: Ca(OH)2, Na2CO3 / H2O 2: OH- View Scheme |
5-chloro-2-methyl-phenol
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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Multi-step reaction with 2 steps 1: (i) (oxidation), (ii) (hydrolysis) 2: OH- View Scheme |
methyl 2-methoxy-4-chlorobenzoate
4-chloro-2-methoxybenzaldehyde
tetrapropylammonium perruthennate
(4-chloro-2-methoxy-phenyl)methanol
4-chloro-2-methoxybenzaldehyde
Conditions | Yield |
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With 4-methyl-morpholine; molecular sieve In dichloromethane |