4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

Base Information

Chemical Name:4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene
CAS No.:947546-26-1
Molecular Formula:C₂₂H₁₅F₃
Molecular Weight:336.356
Hs Code.:

Synonyms:4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

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Technology Process of 4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

There total 6 articles about 4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 947546-77-2
C₁₆H₉I₂F₃

: 590-15-8
trans-2-propenyl bromide

: 947546-26-1
4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

Guidance literature:: trans-2-propenyl bromide; With n-butyllithium; In tetrahydrofuran;

With zinc(II) chloride; In tetrahydrofuran;

C₁₆H₉I₂F₃; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 12h; Further stages.;
DOI:10.1002/anie.200700022

Reference yield:

: 947546-75-0
2-bromo-1-ethynyl-4-methylbenzene

: 947546-26-1
4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / triethylamine / Pd(PPh₃)4; CuI / 6 h / 60 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: 98 percent / I₂ / tetrahydrofuran / 2 h

3.1: n-BuLi / tetrahydrofuran

3.2: ZnCl₂ / tetrahydrofuran

3.3: 68 percent / Pd(PPh₃)4 / tetrahydrofuran / 12 h / 60 °C

With n-butyllithium; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1002/anie.200700022

Reference yield:

: 935223-82-8
2-bromo-4-methyl-1-[2-(trimethylsilyl)ethynyl]benzene

: 947546-26-1
4-methyl-2-(prop-1-ynyl)-1-((2-(prop-1-ynyl)-4-(trifluoromethyl)phenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / K₂CO₃ / CH₂Cl₂; methanol / 12 h / 20 °C

2.1: 85 percent / triethylamine / Pd(PPh₃)4; CuI / 6 h / 60 °C

3.1: n-BuLi / tetrahydrofuran / -78 °C

3.2: 98 percent / I₂ / tetrahydrofuran / 2 h

4.1: n-BuLi / tetrahydrofuran

4.2: ZnCl₂ / tetrahydrofuran

4.3: 68 percent / Pd(PPh₃)4 / tetrahydrofuran / 12 h / 60 °C

With n-butyllithium; potassium carbonate; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.200700022