2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Base Information

Chemical Name:2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide
CAS No.:1387561-20-7
Molecular Formula:C₁₈H₁₈BrF₃N₄O₆S
Molecular Weight:555.329
Hs Code.:

Synonyms:2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

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Chemical Property of 2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

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Technology Process of 2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

There total 3 articles about 2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1387561-19-4
2-[2-(2-bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

: 1387561-20-7
2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Guidance literature:: With ammonia; In methanol; at 55 ℃; for 36h; Sealed vial;

Reference yield:

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1387561-20-7
2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

2: ammonia / methanol / 36 h / 55 °C / Sealed vial

With ammonia; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1387560-90-8
2-bromo-5-fluoro-4-(2-methylaziridin-2-yl)pyridine

: 1387561-20-7
2-[2-(2-Bromo-5-fluoro-pyridin-4-yl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3.67 h / 20 °C / 4? molecular sieves

3: ammonia / methanol / 36 h / 55 °C / Sealed vial

With 4-methyl-morpholine; aluminum oxide; ammonia; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;