4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:644968-01-4
Molecular Formula:C₁₈H₂₆FNO₄
Molecular Weight:339.407
Hs Code.:

Synonyms:4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(5-fluoro-2-methoxybenzyl)-4-hydroxypiperidine-1-carboxylate 97%
5g
$ 933.00

Crysdot
tert-Butyl4-(5-fluoro-2-methoxybenzyl)-4-hydroxypiperidine-1-carboxylate 97%
1g
$ 311.00

Total 3 raw suppliers

Chemical Property of 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(5-fluoro-2-methoxybenzyl)-4-hydroxypiperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 2 articles about 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 644968-01-4
4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: 2-bromo-4-fluoro-1-methoxybenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at 30 ℃; for 16h;

1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester; With copper(I) bromide dimethylsulfide complex; at 30 ℃; for 3h;
DOI:10.1016/j.bmcl.2012.12.095

Reference yield:

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 188132-02-7
(5-fluoro-2-methoxyphenyl)magnesium bromide

: 644968-01-4
4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With copper(I) bromide dimethyl sulphide complex; In tetrahydrofuran; at 30 ℃; for 3h;

Reference yield: 31.0%

: 644968-01-4
4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

: 644968-05-8
5-fluorospiro[1-benzofuran-2,4'-piperidine] hydrochloride

Guidance literature:: 4-[(5-fluoro-2-methoxyphenyl)methyl]-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; With hydrogen bromide; In acetic acid; for 29h; Heating / reflux;

With hydrogenchloride; In water;