Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI)

Base Information

• Chemical Name: Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI)
• CAS No.: 5601-10-5
• Molecular Formula: C8H8N4O2
• Molecular Weight: 192.177
• Mol file: 5601-10-5.mol

Synonyms:Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI)

Chemical Property of Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI)

Chemical Property:

• PSA: 89.66000
• LogP: 2.16810

Purity/Quality:

1-methyl-6-nitro-1H-Benzimidazol-2-amine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI)

There total 3 articles about Benzimidazole, 2-amino-1-methyl-6-nitro- (7CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bromocyane (506-68-3) + N2-methyl-4-nitrobenzene-1,2-diamine (95576-84-4) → 1-methyl-6-nitro-1H-benzo[d]imidazol-2-amine (5601-10-5)

Guidance literature:

In methanol; water; at 50 ℃; for 1h;

Reference yield:

1-methyl-6-nitro-1H-benzoimidazole (5381-79-3) → 7-amino-1-methyl-6-nitrobenzimidazole + 1-methyl-6-nitro-1H-benzo[d]imidazol-2-amine (5601-10-5)

Guidance literature:

With potassium tert-butylate; N,N,N-trimethylhydrazinium iodide; In dimethyl sulfoxide; at 20 ℃; for 10h;

DOI:10.1007/s11178-005-0339-z

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → 1-methyl-6-nitro-1H-benzo[d]imidazol-2-amine (5601-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide; water / 18 h / 20 °C

2: water; methanol / 1 h / 50 °C

With sodium carbonate; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

1-methyl-6-nitro-1H-benzoimidazole

bromocyane

N₂-methyl-4-nitrobenzene-1,2-diamine

4-Nitrophenylene-1,2-diamine

Refernces

• 1、 Bella, Maros,Milata, Viktor,Larina, Lyudmila I.. "2-amino-X-nitrobenzimidazoles as precursors of food-borne carcinogens: A new approach to IQ synthesis". experimental part. p. 293 - 296. Retrieved 2012/06/04.