5381-79-3

Basic information

• Product Name: 1H-Benzimidazole,1-methyl-6-nitro-(9CI)
• Synonyms: 1H-Benzimidazole,1-methyl-6-nitro-(9CI);1-methyl-6-nitrobenzimidazole;1-methyl-6-nitro-benzimidazole
• CAS NO: 5381-79-3
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Product Categories: BENZIMIDAZOLE
• Mol File: 5381-79-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 358.6°Cat760mmHg
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 2.52E-05mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 1H-Benzimidazole,1-methyl-6-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,1-methyl-6-nitro-(9CI)(5381-79-3)
• EPA Substance Registry System: 1H-Benzimidazole,1-methyl-6-nitro-(9CI)(5381-79-3)

Safety Data

• Hazardous Substances Data: 5381-79-3(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 1-methyl-6-nitro-(9CI) is a chemical compound with the molecular formula C9H8N4O2. It is a derivative of benzimidazole, a heterocyclic aromatic organic compound. The presence of a methyl group and a nitro group in the molecular structure distinguishes this compound. It is used in various industries as a building block for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical may have potential applications in the fields of medicine, agriculture, and materials science due to its unique molecular structure and properties. However, it is important to handle this chemical with care and follow safety guidelines when working with it due to its potential hazards.

InChI:InChI=1/C8H7N3O2/c1-10-5-9-7-3-2-6(11(12)13)4-8(7)10/h2-5H,1H3

Upstream product

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• 94-52-0 6-nitro-1H-benzo[d]imidazole 
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• 408509-08-0 toluene-4-sulfonic acid-(2-amino-N-methyl-5-nitro-anilide) 
• 50-00-0 formaldehyd 

Downstream Products

• 5601-10-5 1-methyl-6-nitro-1H-benzo[d]imidazol-2-amine 
• 10394-38-4 1-methyl-1H-benzo[d]imidazol-5-amine 
• 26530-93-8 1-methyl-6-amino-1H-benzo[d]imidazole 

Relevant articles and documents

QUINAZOLINE COMPOUNDS USEFUL AS M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to compounds of Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R7, R8, R9, R11, n and p are defined herein. The compounds of Formula (I) are M1 receptor positive allosteric modulators that are useful in the treatment of diseases in which the M1 receptor is involved, including Alzheimer's disease, schizophrenia, pain and sleep disorders. The invention also relates to pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier, and to methods of using the compounds of Formula (I) in the treatment of diseases mediated by the M1 receptor.

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.