4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

Base Information

Chemical Name:4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester
CAS No.:936548-95-7
Molecular Formula:C₂₅H₂₇BrFN₅O₅
Molecular Weight:576.422
Hs Code.:

Synonyms:4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

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Chemical Property of 4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

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Technology Process of 4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

There total 2 articles about 4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 936548-94-6
(4-bromo-2-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine

: 936548-95-7
4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

Guidance literature:: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

(4-bromo-2-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4.33333h;

Reference yield: 50.0%

: 936548-94-6
(4-bromo-2-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 936548-95-7
4-[4-(4-bromo-2-fluoro-phenylamino)-6-nitro-quinazolin-7-yloxymethyl]-piperidin-1-carboxylic acid t-butylester

Guidance literature:: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

(4-bromo-2-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4.33333h;