(1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

Base Information

Chemical Name:(1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane
CAS No.:140710-27-6
Molecular Formula:C₂₄H₃₂O₄Si
Molecular Weight:412.601
Hs Code.:

Synonyms:(1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

Chemical Property:

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Technology Process of (1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

There total 12 articles about (1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133592-85-5
3-(2-Methyl-4-oxo-4H-[1,3]dioxin-2-yl)-propionic acid allyl ester

: 140710-27-6
(1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / ethyl acetate / 3 h / Irradiation

2: H₂O / acetonitrile / 8 h / 50 °C

3: imidazole / dimethylformamide / 48 h

4: 100 percent / LiBHEt₃ / tetrahydrofuran / 3 h / Ambient temperature

5: 72 h / 28 °C / lipase MY

With 1H-imidazole; water; lithium triethylborohydride; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0957-4166(00)80211-6

Reference yield:

: 133592-85-5
3-(2-Methyl-4-oxo-4H-[1,3]dioxin-2-yl)-propionic acid allyl ester

: 140710-27-6
Acetic acid (1S,2S,3R)-2-(tert-butyl-diphenyl-silanyloxy)-3-hydroxymethyl-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / ethyl acetate / 3 h / Irradiation

2: H₂O / acetonitrile / 8 h / 50 °C

3: imidazole / dimethylformamide / 48 h

4: 100 percent / LiBHEt₃ / tetrahydrofuran / 3 h / Ambient temperature

5: 72 h / 28 °C / lipase MY

With 1H-imidazole; water; lithium triethylborohydride; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0957-4166(00)80211-6

Reference yield:

: 133592-90-2,142758-71-2
(1R,7S,9S,13R)-1-Methyl-5,11,12-trioxa-tricyclo[5.4.2.0^9,13]tridecane-4,10-dione

: 140710-27-6
(1R,2R,3S)-1-acetoxymethyl-2-(tert-butyldiphenylsiloxy)-3-hydroxymethylcyclobutane

Guidance literature:: Multi-step reaction with 4 steps

1: H₂O / acetonitrile / 8 h / 50 °C

2: imidazole / dimethylformamide / 48 h

3: 100 percent / LiBHEt₃ / tetrahydrofuran / 3 h / Ambient temperature

4: 72 h / 28 °C / lipase MY

With 1H-imidazole; water; lithium triethylborohydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0957-4166(00)80211-6