2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

Base Information

Chemical Name:2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide
CAS No.:916155-81-2
Molecular Formula:C₂₀H₂₀ClN₃O₂S
Molecular Weight:401.917
Hs Code.:

Synonyms:2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

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Chemical Property of 2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

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Technology Process of 2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

There total 6 articles about 2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 900448-53-5
2-[(p-tolylamino)methyl]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

: 79-04-9
chloroacetyl chloride

: 916155-81-2
2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 2h;

Reference yield:

: 89567-03-3
2-(chloromethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

: 916155-81-2
2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / ethanol / 7 h / Heating

2: 70 percent / potassium carbonate / acetone / 2 h / 20 °C

With potassium carbonate; In ethanol; acetone;

Reference yield:

: 20886-87-7
2-(2-chloroacetylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amide

: 916155-81-2
2-chloro-N-(4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-ylmethyl)-N-p-tolyl acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / polyphosphate ester / 8 h / Heating

2: 74 percent / ethanol / 7 h / Heating

3: 70 percent / potassium carbonate / acetone / 2 h / 20 °C

With polyphosphate ester; potassium carbonate; In ethanol; acetone;