benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

Base Information

Chemical Name:benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate
CAS No.:874384-08-4
Molecular Formula:C₃₄H₃₉NO₅
Molecular Weight:541.687
Hs Code.:

Synonyms:benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

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Technology Process of benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

There total 9 articles about benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 874384-02-8
(S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester

: 121998-80-9
(R)-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxoethyl]phosphonic acid dimethyl ester

: 874384-08-4
benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; lithium chloride; In acetonitrile; at 20 ℃; for 72h;
DOI:10.1021/jo0518250

Reference yield:

: 874384-01-7
benzyl (S)-2-(dibenzylamino)pent-4-enoate

: 874384-08-4
benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

Guidance literature:: Multi-step reaction with 2 steps

1: xantphos; H₂ / HRh(CO)(PPh₃)3 / toluene / 96 h / 40 °C / 15200 Torr

2: 87 percent / LiCl; ethyldiisopropylamine / acetonitrile / 72 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium chloride; carbonylhydridetris(triphenylphosphine)rhodium(I); In toluene; acetonitrile; 2: Wittig-Horner-Emmons reaction;
DOI:10.1021/jo0518250

Reference yield:

: 16338-48-0
L-allylglycine

: 874384-08-4
benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaOH; Na₂CO₃ / H₂O / 1.25 h / Heating

2: xantphos; H₂ / HRh(CO)(PPh₃)3 / toluene / 96 h / 40 °C / 15200 Torr

3: 87 percent / LiCl; ethyldiisopropylamine / acetonitrile / 72 h / 20 °C

With sodium hydroxide; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium chloride; carbonylhydridetris(triphenylphosphine)rhodium(I); In water; toluene; acetonitrile; 3: Wittig-Horner-Emmons reaction;
DOI:10.1021/jo0518250