874384-02-8

Basic information

• Product Name: (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester
• Synonyms: (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester
• CAS NO: 874384-02-8
• Molecular Weight: 415.532
• Mol File: 874384-02-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester(874384-02-8)
• EPA Substance Registry System: (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester(874384-02-8)

Safety Data

• Hazardous Substances Data: 874384-02-8(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 874384-01-7 benzyl (S)-2-(dibenzylamino)pent-4-enoate 
• 100-39-0 benzyl bromide 
• 16338-48-0 L-allylglycine 
• 167905-35-3 (S)-2-dibenzylaminopentanedioic acid dibenzyl ester 
• 850209-98-2 (S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester 
• 850209-99-3 2-dibenzylamino-5-oxo-pentanoic acid benzyl ester 
• 874384-03-9 (E)-(S)-2-Dibenzylamino-6-methoxy-hex-5-enoic acid benzyl ester 

Downstream Products

• 329966-94-1 (S)-methyl 7-(tert-butoxycarbonylamino)-8-oxo-8-(phenylamino)octanoate 
• 157618-75-2 (-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone 
• 874384-21-1 (R)-1-((S)-2-{2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-dimethyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-propionylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid 
• 874384-22-2 (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid 
• 874384-07-3 (2S,9S,E)-2-(dibenzylamino)-9-(tert-butyldimethylsilyloxy)-8-oxo-6-decenoic acid benzyl ester 
• 874384-05-1 2-(S)-(dibenzylamino)-8-oxo-6-decenoic acid benzyl ester 
• 874384-08-4 benzyl (2S)-2-(dibenzylamino)-8-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-8-oxo-6-octenoate 

Relevant articles and documents

Diastereoselective and Branched-Aldehyde-Selective Tandem Hydroformylation-Hemiaminal Formation: Synthesis of Functionalized Piperidines and Amino Alcohols

Starting from readily available allylglycine, a tandem hydroformylation-hemiaminal formation reaction has been developed for the synthesis of chiral functionalized piperidines, with very good diastereoselectivity and branched regioselectivity using Rh/(S,

Synthesis of 2-amino-8-oxodecanoic acids (Aodas) present in natural hystone deacetylase inhibitors

Differently substituted 2-amino-8-oxodecanoic acids (Aodas), present in naturally occurring inhibitors of hystone deacetylase (HDAC), have been prepared using a convergent approach. The configuration in position 2 was derived from enantiomerically pure allylglycine or glutamic acid, whereas the stereochemistry of the substituent in position 9 derived from lactic acid or glyceraldehyde derivatives. Starting from allylglycine, (S)-Aodas, protected at the nitrogen as Boc or Fmoc, were obtained in four steps in about 30% overall yield. These products have been used to prepare a simplified analogue of a natural cyclic tetrapeptide HDAC inhibitor by SPPS.