methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Base Information

Chemical Name:methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate
CAS No.:1233249-63-2
Molecular Formula:C₂₇H₂₂ClNO₄
Molecular Weight:459.929
Hs Code.:

Synonyms:methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Chemical Property of methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Technology Process of methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

There total 11 articles about methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1875-88-3
2-(4-Chlorophenyl)ethanol

: 1233249-60-9
4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-l-yl]carbonyl}benzoic acid

: 1233249-63-2
methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 1875-88-3
2-(4-Chlorophenyl)ethanol

: 1233249-55-2
methyl {1-[(4-hydroxyphenyl)carbonyl]isoquinolin-4-yl} acetate

: 1233249-63-2
methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: With tributylphosphine; diamide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

: 1233249-63-2
methyl [1-({4-[2-(4-chlorophenyl)ethoxy]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 1 h / 50 °C

2: tributylphosphine; diamide / tetrahydrofuran / 18 h / 20 °C

With tributylphosphine; diamide; trifluoroacetic acid; In tetrahydrofuran; chloroform;