tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

Base Information

Chemical Name:tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate
CAS No.:1233249-59-6
Molecular Formula:C₂₄H₂₃NO₅
Molecular Weight:405.45
Hs Code.:

Synonyms:tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

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Chemical Property of tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

Chemical Property:

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Technology Process of tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

There total 10 articles about tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₁NO₅

: 18107-18-1
diazomethyl-trimethyl-silane

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233249-58-5
1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl)isoquinoline-4-carboxylic acid

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / chloroform / 20 °C

2.1: tetrahydrofuran; acetonitrile

2.2: 20 °C

3.1: diazomethyl-trimethyl-silane / 20 °C

With oxalyl dichloride; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; acetonitrile; 2.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-57-4
methyl 1-{[4-(tert-butoxycarbonyl)phenyl]carbonyl}isoquinoline-4-carboxylate

: 1233249-59-6
tert-butyl 4-{[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]carbonyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; water; sodium hydroxide / 0 - 20 °C

2.1: oxalyl dichloride / chloroform / 20 °C

3.1: tetrahydrofuran; acetonitrile

3.2: 20 °C

4.1: diazomethyl-trimethyl-silane / 20 °C

With methanol; oxalyl dichloride; water; sodium hydroxide; diazomethyl-trimethyl-silane; In tetrahydrofuran; chloroform; acetonitrile; 3.2: Wolff rearrangement;
DOI:10.1016/j.bmcl.2012.03.009