4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

Base Information

• Chemical Name: 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine
• CAS No.: 1639423-99-6
• Molecular Formula: C₂₀H₁₃ClN₂O₂
• Molecular Weight: 348.788

Synonyms:4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

Chemical Property of 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

There total 2 articles about 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-amino-2,3-dihydro[1]benzofuro[3,2-b]oxepin-4-carbonitrile (1374774-32-9) + N,N-dimethylbenzamide (611-74-5) → 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine (1639423-99-6)

Guidance literature:

N,N-dimethylbenzamide; With trichlorophosphate; at 0 ℃; for 1h;

5-amino-2,3-dihydro[1]benzofuro[3,2-b]oxepin-4-carbonitrile; at 80 ℃; for 1.5h;

DOI:10.1002/jhet.1539

Reference yield:

3-(3-cyanopropoxy)[1]benzofuran-2-carbonitrile (1374774-23-8) → 4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine (1639423-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran

2.1: trichlorophosphate / 1 h / 0 °C

2.2: 1.5 h / 80 °C

With potassium tert-butylate; trichlorophosphate; In tetrahydrofuran;

DOI:10.1002/jhet.1539

Reference yield: 96.0%

4-chloro-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine (1639423-99-6) + ethanolamine (141-43-5) → 4-(2-hydroxyethylamino)-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine (1639454-68-4)

Guidance literature:

In 1,4-dioxane; for 6h; Reflux;

DOI:10.1002/jhet.1539

upstream raw materials:

3-(3-cyanopropoxy)[1]benzofuran-2-carbonitrile

5-amino-2,3-dihydro[1]benzofuro[3,2-b]oxepin-4-carbonitrile

N,N-dimethylbenzamide

Downstream raw materials:

4-amino-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

4-methylamino-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

4-dimethylamino-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

4-ethylamino-2-phenyl-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine

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