1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

Base Information

Chemical Name:1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea
CAS No.:239482-65-6
Molecular Formula:C₁₉H₂₇ClN₂O₄S
Molecular Weight:414.953
Hs Code.:

Synonyms:1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

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Technology Process of 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

There total 1 articles about 1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 622-95-7
4-chlorobenzyl bromide

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 239482-65-6
1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

Guidance literature:: N,N'-bis-Boc-S-methyl-isothiourea; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

4-chlorobenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jm990952j

Reference yield:

: 239482-65-6
1,3'-bis(tert-butoxycarbonyl)-1-(4-chlorobenzyl)-2-methyl-2-thiopseudourea

: N-(4-chlorobenzyl)-N'-(3-pyrrolidin-1-ylpropyl)guanidine bis-hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1: 1.14 g / tetrahydrofuran; H₂O / 1 h / Heating

2: 95 percent / HCl / dioxane / 16 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; water; 1: Substitution / 2: acidolysis;
DOI:10.1021/jm990952j