12-Methoxyabieta-8,11,13-trien-20-al

Base Information

• Chemical Name: 12-Methoxyabieta-8,11,13-trien-20-al
• CAS No.: 57397-33-8
• Molecular Formula: C21H30O2
• Molecular Weight: 314.46
• Mol file: 57397-33-8.mol

Synonyms:12-Methoxyabieta-8,11,13-trien-20-al

Chemical Property of 12-Methoxyabieta-8,11,13-trien-20-al

Chemical Property:

• Boiling Point: 422.9±45.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.041±0.06 g/cm3(Predicted)
• LogP: 5.02780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 12-Methoxyabieta-8,11,13-trien-20-al

There total 38 articles about 12-Methoxyabieta-8,11,13-trien-20-al which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

((4aR,10aR)-7-Isopropyl-6-methoxy-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthren-4a-yl)-methanol (57397-36-1,83150-94-1,128386-29-8) → 12-methoxy-5βH-abieta-8,11,13-trien-20-al (57397-33-8,128386-27-6,128386-30-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; 1) -78 deg C, 15 min, 2) -78 deg C, 5 min;

Reference yield:

12-methoxyabieta-8,11,13-trien-20-ol (57397-36-1) → 12-methoxyabieta-8,11,13-trien-20-al (57397-33-8)

Guidance literature:

With chromium(VI) oxide; In acetone; at 0 ℃; for 0.05h; Yield given;

DOI:10.1016/S0031-9422(00)82465-6

Reference yield:

12-methoxy-5H-abieta-6,8,11,13-tetraene-20-nitrile (128291-75-8,128302-13-6) → 12-methoxy-5βH-abieta-8,11,13-trien-20-al (57397-33-8,128386-27-6,128386-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent palladium-on-carbon / ethyl acetate / 8 h

2: di-isobutylaluminium hydride / toluene / 1 h / -78 °C

With diisobutylaluminum hydride; hydrogen; palladium on activated charcoal; In ethyl acetate; toluene;

upstream raw materials:

((4aR,10aR)-7-Isopropyl-6-methoxy-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthren-4a-yl)-methanol

12-methoxy-5α,βH-abieta-8,11,13-triene-20-nitrile

12-methoxy-5αH-abieta-8,11,13-triene-20-nitrile

3,3-dimethylpent-4-enal

Downstream raw materials:

12-methoxy-5βH-abieta-8,11,13-trien-20-al

Refernces

• 1、 Koyabashi, Koji,Nishino, Chikao,Tomita, Hirofumi,Fukushima, Masako. "ANTIFUNGAL ACTIVITY OF PISIFERIC ACID DERIVATIVES AGAINST THE RICE BLAST FUNGUS". . p. 3175 - 3180. Retrieved 2007/10/02.