tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313441-35-8
Molecular Formula:C₃₀H₃₄N₄O₃
Molecular Weight:498.625
Hs Code.:

Synonyms:tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

There total 5 articles about tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1313441-23-4
tert-butyl (1-(4-(2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

: 74-88-4
methyl iodide

: 1313441-35-8
tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1313441-20-1
ethyl 3-((6-(4-(1-((tert-butoxycarbonyl)amino)cyclobutyl)phenyl)-3-nitro-5-phenylpyridin-2-yl)amino)propanoate

: 1313441-35-8
tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran / 50 °C

2: hydrogen / palladium on activated charcoal / tetrahydrofuran / 20 °C / 1500.15 Torr / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1313440-75-3
tert-butyl (1-(4-(6-chloro-5-nitro-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313441-35-8
tert-butyl (1-(4-(1-methyl-2-oxo-8-phenyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepin-7-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 1.5 h / 80 °C / Microwave irradiation; Inert atmosphere

2: sodium hydroxide / tetrahydrofuran / 50 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran / 20 °C / 1500.15 Torr / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;