N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide
CAS No.:137105-32-9
Molecular Formula:C₂₄H₃₅NO₇
Molecular Weight:449.544
Hs Code.:

Synonyms:N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

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Chemical Property of N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

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Technology Process of N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

There total 5 articles about N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 329899-64-1
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 137105-36-3
4-pivaloylaminobenzyl chloride

: 137105-32-9
N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

Guidance literature:: With barium dihydroxide; barium(II) oxide; In N,N-dimethyl-formamide; for 1.3h; Ambient temperature;
DOI:10.1016/0040-4039(91)80616-E

Reference yield: 72.0%

: 329899-64-1
1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

: 137105-38-5
p-pivalolaminobenzyl 2,2,2-trichloroacetimidate

: 137105-32-9
N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

Guidance literature:: trifluorormethanesulfonic acid; In diethyl ether; for 9h; Ambient temperature;
DOI:10.1016/0040-4039(91)80616-E

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 137105-32-9
N-{4-[(3aR,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxymethyl]-phenyl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

2: 93 percent / SOCl₂, DMF / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 89 percent / Ba(OH)2 - BaO / dimethylformamide / 1.3 h / Ambient temperature

With barium dihydroxide; thionyl chloride; triethylamine; N,N-dimethyl-formamide; barium(II) oxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(91)80616-E