3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

Base Information

Chemical Name:3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate
CAS No.:213127-78-7
Molecular Formula:C₁₉H₂₇F₂O₇P
Molecular Weight:436.39
Hs Code.:

Synonyms:3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

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Chemical Property of 3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

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Technology Process of 3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

There total 6 articles about 3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 108-24-7
acetic anhydride

: 213127-72-1
diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

: 213127-78-7
3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

Guidance literature:: With dmap; triethylamine; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 213127-78-7
3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

5: 84 percent / triethylamine; 4-dimethylaminopyridine / 2 h / 20 °C

With dmap; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; triethylamine; copper(I) bromide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction / 5: Acetylation;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 624-31-7
4-tolyl iodide

: 213127-78-7
3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

5: 84 percent / triethylamine; 4-dimethylaminopyridine / 2 h / 20 °C

With dmap; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; triethylamine; copper(I) bromide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction / 5: Acetylation;
DOI:10.1016/S0040-4020(98)00586-9