tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

Base Information

Chemical Name:tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate
CAS No.:1613270-23-7
Molecular Formula:C₁₆H₂₉NO₄
Molecular Weight:299.411
Hs Code.:

Synonyms:tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

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Chemical Property of tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

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Technology Process of tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

There total 13 articles about tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1613270-22-6
tert-butyl-N-(1-(trans-4-(2-(benzyloxy)ethyl)cyclohexyl)-3-oxopropyl)carbamate

tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate: 1613270-23-7
tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

: 62141-26-8
ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate

tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate: 1613270-23-7
tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C

2.2: 20 °C

3.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

4.2: -40 - 20 °C

5.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

5.2: 2.5 h / 0 - 20 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

6.2: 0.58 h / -78 - 20 °C

7.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

8.1: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere

9.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C

10.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

11.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / 1,4-dioxane; water / 18 h / 20 °C

11.2: 4 h / 20 °C

12.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; osmium(VIII) oxide; lithium aluminium tetrahydride; oxalyl dichloride; diborane-dimethylsulfide complex; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetonitrile; mineral oil; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination / 6.1: |Swern Oxidation / 6.2: |Swern Oxidation;

Reference yield:

: 51656-91-8
ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate

tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate: 1613270-23-7
tert-butyl 1-(trans-4-(2-hydroxyethyl)cyclohexyl)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 13 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1810.07 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C

3.2: 20 °C

4.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

5.2: -40 - 20 °C

6.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

6.2: 2.5 h / 0 - 20 °C

7.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

7.2: 0.58 h / -78 - 20 °C

8.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

9.1: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere

10.1: hydrogenchloride / methanol; 1,4-dioxane / 0.5 h / 20 °C

11.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

12.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / 1,4-dioxane; water / 18 h / 20 °C

12.2: 4 h / 20 °C

13.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; osmium(VIII) oxide; lithium aluminium tetrahydride; oxalyl dichloride; diborane-dimethylsulfide complex; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetonitrile; mineral oil; 5.1: |Wittig Olefination / 5.2: |Wittig Olefination / 7.1: |Swern Oxidation / 7.2: |Swern Oxidation;