51656-91-8

Basic information

• Product Name: ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate
• Synonyms: ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate;ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate-24;Ethyl 1,4-dioxaspiro[4.5]dec-8-ylideneacetate;8-[(Ethoxycarbonyl)methylidene]-1,4-dioxaspiro[4.5]decane;NSC 649463;2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)acetic acid ethyl ester
• CAS NO: 51656-91-8
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.26892
• Mol File: 51656-91-8.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 327.8°C at 760 mmHg
• Flash Point: 143.1°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.000197mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(51656-91-8)
• EPA Substance Registry System: ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate(51656-91-8)

Safety Data

• Hazardous Substances Data: 51656-91-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate, also known as spiroacetals, is a chemical compound with the molecular formula C12H18O4. It is a spiroacetal compound that is commonly used as a flavoring agent in the food and beverage industry, and as a fragrance ingredient in the cosmetics and personal care products industry. It is also used in the synthesis of various pharmaceuticals and organic compounds. Ethyl 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate has a fruity odor and is often described as having a sweet, floral, and slightly woody aroma. It is a colorless to pale yellow liquid at room temperature and is soluble in most organic solvents. Due to its pleasant odor and versatile uses, this compound is in high demand in various industries.

InChI:InChI=1/C12H18O4/c1-2-14-11(13)9-10-3-5-12(6-4-10)15-7-8-16-12/h9H,2-8H2,1H3

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 311-46-6 ethyl 2-(dimethoxyphosphoryl)acetate 
• 87151-60-8 1-oxaspiro[4.5]decan-8-one 
• 637-88-7 1,4-Cyclohexanedione 
• 107-83-5 2-Methylpentane 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 35752-46-6 phosphonoacetic acid ethyl ester 
• 107-21-1 ethylene glycol 
• 159454-98-5 (4-oxocyclohexylidene)acetic acid ethyl ester 
• 38868-10-9 triethyl phosphonoacetate anion 

Downstream Products

• 1166829-72-6 ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate 
• 1421914-19-3 8-(4-phenethyl-6-phenylhexa-2,3-dien-1-ylidene)-1,4-dioxaspiro[4.5]decane 
• 1421914-30-8 8-(2-tosylethylidene)-1,4-dioxaspiro[4.5]decane 
• 1421914-38-6 8-[2-(p-tolylthio)ethylidene]-1,4-dioxaspiro[4.5]decane 
• 1350476-35-5 [4-({[(1Z)-2-tert-butyI-2-methyl-1-oxido-1λ5-diazan-1-ylidene]amino}oxy)cyclohexyl]acetic acid 
• 1350476-36-6 ethyl [4-({[(1Z)-2-tert-butyI-2-methyl-1-oxido-1λ5-diazan-1-ylidene]amino}oxy)cyclohexyl]acetate 
• 1350434-23-9 ethyl [4-({[4-(trifluoromethyl)phenyl]sulfonyl}oxy)cyclohexyl]acetate 
• 58012-34-3 ethyl 4-oxocyclohexaneacetate 
• 62141-22-4 2-(4-hydroxycyclohexyl)acetic acid ethyl ester 
• 134136-04-2 (1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid 
• 1292321-59-5 C₂₂H₂₇F₂N₃O₃S 
• 1292321-58-4 C₂₂H₂₅F₅N₂O₃S 
• 1292321-32-4 C₂₀H₃₀F₂N₂O₂ 
• 1292321-57-3 C₂₁H₂₇F₂N₃O₂S 

Relevant articles and documents

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SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR

Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The inhibitor of the present invention has a structure as represented by general formula (I), wherein the definitions of Ar, E, Y, X, V, D, W, B, ring A and ring B are as shown in the description and claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound of general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for preparing a medicament for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.